New Manila is located on west central portion of the city. This is a largely residential district that was named after Quezon City's neighbor to the southwest, Manila. The area was first settled after the second World War by some of the more affluent families who wished to escape the stress of living in Manila. As a result, many of the houses here stand on lots measuring 500 square meters and above.

The main thoroughfares are Aurora Boulevard, Gilmore Street, and Eulogio Rodriguez Avenue. Aurora Boulevard begins at the Quezon City - Marikina border and reaches New Manila upon crossing EDSA. Gilmore also crosses Ortigas Avenue, giving it access to Mandaluyong, Pasig, and San Juan cities. Eulogio Rodriguez Avenue diverges from Aurora Boulevard a few meters from EDSA.

Aurora Boulevard is the site of Broadway Centrum, where the first GMA Network entertainment shows were shot. Saint Paul University, Quezon City stands at the corner of Aurora Boulevard and Gilmore Street, across a row of shops specializing in computer equipment and an office of SYKES Asia. Trinity University of Asia, Saint Joseph's College of Quezon City, the Divine Word Seminary and St. Luke's Medical Center are all located along Eulogio Rodriguez Avenue, as are the Quezon Institute and the Philippine Charity Sweepstakes Office.

Also located near New Manila is Quezon City's "Funeral Home Row", Araneta Avenue. This is attributed to the unusually high concentration of funeral homes in the area. Balete Drive, between Aurora Boulevard and Eulogio Rodriguez Avenue, is also the setting for many urban legends. The cathedral of the Roman Catholic Diocese of Cubao is located in Lantana Street, near Eulogio Rodriguez Avenue. The offices and studios of the MOWELFUND is located a few blocks from the cathedral.