This is located between Commonwealth to the east, North Ave to the south, Frisco to the west and Fairview-Sauyo to the north. It got its name from the Grand Old Lady of the Revolution, Melchora Aquino or Tandang Sora, whose remains lie on the Himlayang Pilipino memorial park on what used to be her backyard.

The area is primarily residential with Projects 6 and 8 located here, as are other subdivisions, like Town & Country Gardenville, San Pedro Subdivisions (1, 2, 3, 4, 5, 6, 7, 8), Napocor (NPC) Village, NIA Village, Reymar Subdivision, Villa Corrina, San Miguel Village, Gloria and many more. A large portion of Tandang Sora district is Barangay Bahay Toro, where a historic site of the Philippine Revolution known as Pugad Lawin is located. There are some industrial facilities especially near the Mindanao Avenue area. Culiat, a Muslim compound, is also to be found here, as are the central offices of the Iglesia ni Cristo and New Era University. The transmitter of GMA 7 is located near Culiat.

Also in the area are Congressional Village, Visayas Avenue, and Mindanao Avenue (forming part of C-5).